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Liver fat, visceral fat, lipids, ketones, and insulin are real and measured, but no retatrutide trial has tested insulin sensitivity or longevity as an endpoint

The concept draws from hormesis, a biological phenomenon where low-dose exposure to a substance produces beneficial effects while higher doses might produce neutral or even counterproductive outcomes

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Pevec, D., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., Mise, S., Brcic, I., Kolenc, D., Klicek, R., Banic, T., Sever, M., Kocijan, A., Berkopic, L., Radic, B., Buljat, G., Anic, T., Zoricic, I., Bojanic, I., Sikiric, P